Refractometers For Bioprocessing

    Categories Liquid & Gas Analysis, Bioprocessing

    Process refractometer DCM-20 with Ingold/Sanitary connection for bioprocessing control

    Brand : KXS

    • Description

    KxS process refractometers set the standard for accuracy, hygiene and safety in the bioprocessing industries. Our refractometers seamlessly integrate through Ingold or Sanitary Tri clamp with pilot and high-volume bioreactors and ultrafiltration (UF) systems.

      Typical applications:

    • Fermentation to ensure consistent output quality
    • Membrane filtration efficiency in protein UF separation
    • Blood plasma UF quality control
    • Sucrose density to capture virus rich fractions of influenza vaccines
    • Enhancing evaporation and crystallization with precise steam feed optimization

    Our refractometers feature industry-leading solid optics and are designed for maintenance-free operation with true stand-alone concentration monitoring. They offer a full measurement range of 0-100%, utilizing two independent 4-20mA outputs and a digital Ethernet output for versatile connectivity.

    For enhanced functionality, an optional HMI unit provides a local display and interface, ensuring ease of use.

    KxS Process refractometers, designed for bioprocessing and food industry applications, comply with food safety and safe food contact materials (FCMs) according to U.S. and EU regulations, including European Regulation (EC) No 1935/2004 on materials and articles intended to come into contact with food. We also comply with Commission Regulation (EC) No 2023/2006 on Good Manufacturing Practice (GMP), ensuring that our manufacturing processes are well-controlled so that specifications for FCMs remain in conformity with the legislation.

    Experience the high accuracy and reliability with KxS process refractometers, designed to meet the rigorous safety demands and continous manufacturing (CM) initiative in the bioprocessing industries.

      1” Ingold connection for bioreactors

    • Ingold G1 ¼” 25mm (1”)
    • Insertion length customizable

    KxS process refractometer DCM-20 with Ingold process connection is designed with highest hygienic industry standards to integrate in pilot and high-volume manufacturing bioreactors and ultrafiltration systems.

    • All measurement functions are integrated in the sensor - no transmitter required.
    • Measurement output options include both analog and digital communication protocols: dual analog 4-20mA and Modbus TCP. 
    • External display of different sizes are readily available and connected through the sensor digital port. Computer, tablet or mobile phone with a web browser serves as sensor user interface for accessing diagnostics and settings.  
    • The refractometer does not require any recalibration or regular maintenance. Furthermore, the calibration of each refractometer can be verified using NIST traceable standard refractive index liquids and easy verification procedure.

      Key features

    • nD=1.3200...1.5300 (equals by definition to 0...100%wt)  
    • Optimal footprint​, weight 2.0kg (4.4lbs)​
    • True stand-alone ​

      Optics

    • Solid optics module provides reliable thermal properties and rigidity​.
    • Traditional fiber optics, prone to breakage, replaced with innovative, non-breakable design.
    • Isolated electronics for true concentration temperature compensation.
    • Individual zero-point factory calibration.

      Conformance

    • 3A Sanitary 46-04 Symbol authorization and certified by European Hygienic Engineering and Design Group (EHEDG) Type EL Class I.
    • Surface roughness Ra 0.38 μm (15 μ inch), electropolished (no animal derived ingredients).

    Brochures

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    Manuals

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    Certificates

    3-A Sanitary Standards Certificate 46-04

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    EHEDG Certificate Type EL Class 1

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    DNV Management System Certificate ISO 9001:2015

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    Technical Notes

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    Applications

    Critical inline instrumentation integration aspects in dairy total solids and Brix concentration measurements in membrane filtration systems

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    Application Note 2.01.01 CHO fermentation and cell/protein separation

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    Application Note 2.03.02 Overview of Active Pharmaceutical Ingredient (API) applications

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    Application Note 3.12.01 Side-stream and wastewater treatment

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